Patents

1.“IL10/FC fusion proteins useful as enhancers of immunotherapies” #EP 19198358.4; #PCT/EP2020/076089; Inventors: GUO, Yugang; TANG, Li; XIE, Yu-Qing.

2.“IL-10 expressing cells for enhanced cancer immunotherapies” #EP 21192853.6; Inventors: GUO, Yugang; TANG, Li; ZHAO, Yang.

3.“一种治疗性肿瘤浸润淋巴细胞及其制备方法和应用” 申请号：2022116769776; 申请人：深圳莱芒生物科技有限公司。

4.“一种白细胞介素10的突变体及其制备方法和应用” 申请号：2022116277856; 申请人：深圳莱芒生物科技有限公司。

Publications

1. Qianwen Xu., Yugang Guo., Min Gao., Lei Xue., Hui Xu., Hui Li., Xuhan Zhang., Chongling Liu., Youjia Li., Qian Chen., Jingjing Ren., Karthik Sathiyanadan., Yongxian Hu., Li Tang., He Huang., Xingbing Wang. IL-10-expressing, anti-CD19 CAR T cells for patients with relapsed or refractory B-cell acute lymphoblastic leukaemia: an open-label, single-arm, phase 1 study. The Lancet Haematology. (2025)

2. Bing Feng., Zhiliang Bais., Xiaolei Zhou., Yang Zhao., Yu-Qing Xie., Xinyi Huang.,Yang Liu., Tom Enbar., Rongrong Li., Yi Wang., Min Gao., Lucia Bonati., Rong Fan.,Yugang Guo.,LiTang.The type2 cytokineFc–IL-4 revitalizes exhausted CD8+T cells against cancer.Nature.(2024)

3. Zhiliang Bai.,Bing Feng., Susan E. McClory., Beatriz Coutinho de Oliveira., Caroline Diorio., Céline Gregoire.,Bo Tao., Luojia Yang., Ziran Zhao.,Lei Peng., Giacomo Sferruzza., Liqun Zhou., Xiaolei Zhou., Jessica Kerr., Alev Baysoy.,  Li Tang., Carl H. June.Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission.Nature.(2024)

4. Zhao, Y., Jiangqing, C., Andreatta，Massimo, Feng, B., Xie, Y., Wenes, M., Wang, Y., Gao, M., Hu, X., Romero, P., Carmona, S., Sun, J.*, Guo, Y.* & Tang, L.* IL-10-expressing CAR-T cells resist dysfunction and mediate durable clearance of solid tumors and metastases. Nat. Biotechnol. (2024)

5. Guo, Y., Xie, Y., Gao, M., Zhao, Y., Franco, F., Wenes, M., Siddiqui, I., Bevilacqua, A., Wang, H., Yang, H., Feng, B., Xie, X., Sabatel, C. M., Tschumi, B., Chaiboonchoe, A., Wang, Y., Li, W., Xiao, W., Held, W., Romero, P., Ho, P. & Tang, L. Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity. Nat. Immunol. (2021)